By using the Liquisolid technique, sustained drug delivery systems were developed for the water soluble drugs in which hydrophobic non-volatile solvents are. Abstract. Liquisolid technique is also known as powder solution technology. It is the technique which deals with the solubility enhancement of poorly soluble. Acta Pharm. Mar;57(1) Liquisolid technique as a tool for enhancement of poorly water-soluble drugs and evaluation of their physicochemical.
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Effects of liquisolid formulations on dissolution of naproxen. Lower R values of liquisolid compacts contain relatively smaller amounts of carrier powder cellulosea large amount of fine coating particles silicaand the ratios of their liquid medication per powder substrate are relatively higher.
LIQUISOLID TECHNIQUE: AN APPROACH FOR ENHANCEMENT OF SOLUBILITY
Different concentrations of non-volatile solvents are taken and the drug is dissolved. Type of carrier might affect the unit size of liquisolid tablets.
This procedure involves the fixed height of each liquisolid powder substrate with prepared and fixed weight. In addition, flowability studies are also to be carried out to select the optimal formulae for compression, prior to the compression of the powders the dosage forms such as into tablets and capsules.
A drop of this solution was placed on the surface of the tablet, and pictures were taken using a digital camera. This angle is known as angle of slide. The liquisolid compacts are powdered well and equivalent to 10mg of the drug powder is weighed and diluted using suitable solvent.
Services on Demand Journal. However, the drug techmique profile entirely depends on the characteristics of drug, carrier and vehicle used.
The purpose of this article is to describe about the liquisolid technique like basics, classification, preformulation studies, characterisation, precompression studies, formulation of tablet, postcompression studies, advantages, disadvantages, applications. Components of Tecnique formulations and selection criteria: There are several approaches for solubility enhancement which includes micronization, Nanonisation, use of salt forms, use of surfactant, solid dispersion, and supercritical fluid recrystalization etc.
Surfactants are very useful as absorption enhancers and enhance both dissolution rate as well as permeability of drug. The accurately weighed physical mixtures techniqie liquisolid compacts were taken in a funnel.
It was shown that microcrystalline cellulose had more liquid retention potential in comparison with lactose, and the formulations containing microcrystalline cellulose as a carrier showed a higher dissolution rate. Depending upon internal structure of solid drugs, selection of proper form of drug is with greater solubility is important.
Non-volatile solvent present in the liquisolid system facilitates wetting of drug particles by decreasing interfacial tension between dissolution medium and tablet surface. Drug is solubilized in a maximum molecularly dispersed state.
Optimized sustained release, liquisolid tablets or capsules of water insoluble drugs demonstrate constant dissolution rates zero order release. Liquisolid technique has been classified on the basis of liquisoliv active moieties, viz. Preformulation studies Formulation of liquisolid compacts. The DSC and XPD results showed no changes in crystallinity of the drug and interaction between indomethacin and excipients Avicel and silica during the process.
Liquisolid technique as a new approach to sustain propranolol hydrochloride release from tablet matrices. Both Differential Scanning Electron and X-ray diffraction studies suggested loss of crystallinity upon liquisolid formulation. It is one of the novel techniques which is used for solubility enhancement and bioavailability of poorly water soluble drug.
Formulation and evaluation of rofecoxib liquisolid tablets. Mainly superdisintegrants increases rate of drug release, its wettability and increases solubility of drug particles within short period of time. It is the process in which drug powder is converted in to nanocrystals of sizes nm.
Liquisolid technique is novel and efficient approach for solubility enhancement. This saturated solution is prepared by adding excess amount of drug in non solvent. J Adv Pharm Techniqus Res.
The Liquisolid technique: an overview
According to this equation, stagnant diffusion layer thickness is h, and formed by the dissolving liquid around the drug particles.
It should not be highly viscous organic solvent system. The compressibility index has been proposed as an indirect measure of bulk density, size and shape, surface area, moisture content and cohesiveness of material because all of these ca influence the compressibility index.
Bioavailability of many class II and class IV drugs get enhanced by using liquisolid technique. Use of salt forms: Fourier transformed infra red spectroscopy: Hence, the liquisolid technology allows the transformation of liquid systems into solid drug delivery systems.
Pharmaceutical applications of liquisolid technique
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. Angle of Repose Method: Liquisolid system demonstrated for drugs which would enhance the dissolution profile and the absorption capacity of water insoluble solid drugs such as digoxin, digitoxin, prednisolone, hydrocortisone, famotidine, carbamazepine, water insoluble vitamins, hydrochlorothiazide, Domperadone, spiranolactone, Carvedilol, Naproxen, and Meloxicam.
Powdered liquid drug Powdered drug solutions. The process is also called as techniqus milling. The angle of repose physical mixtures of liquisolid compacts were determined by fixed funnel method. Bioavailability depends on solubility of drug.
In order for a drug to be absorbed into the systemic circulation following oral administration, the drug must be dissolved in the gastric fluids. Liquiso,id evaluation of hydrochlorothiazide liquisolid tablet in beagles dogs. Effect of some commercial grades of microcrystalline cellulose on flowability, compressibility and dissolution profile of piroxicam liquisolid compacts.
Determination of angle of slide is done by weighing the required amount of carrier material and placed at one end of a metal plate with a polished surface. Due to this the liquid layer gets converted in the solid layer and this gives the dry, non adherent, free flowing powder particles. The effect of type and concentration of vehicles on the dissolution rate of a poorly soluble drug indomethacin from liquisolid compacts.
In the third step suitable superdisintegrants like sodium starch Glycolate or Crosspovidone is added in the prepared mixture with continuous shaking in a mortar.