Analyse moléculaire et diagnostic prénatal de la b-thalassémie: à propos de notre expérience en Tunisie centrale Volume 58, numéro 4, Juillet – Août Le terme thalassémie est un terme générique pour désigner un tableau clinique résultant d’une diminution quantitative de la synthèse d’une chaîne de globine. selenium, and copper in 64 children with B-thalassaemia major and 63 age- and zinc, sólénium et cuivre sériques chez 64 enfants atteints de B-thalassemie.
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Beta thalassemia – Wikipedia
Repeated blood transfusions thalassemoe lead to build-up of tahlassemie overloadultimately resulting in iron toxicity. Genetic analysis of amplified DNA with immobilized sequence specific oligonucleotide probes. After the narrowing of patients, the HbA2 levels were tested presenting 77 patients with beta thalassemia. Kochar’s Clinical Medicine for Students. Based on symptoms, tests are ordered for a differential diagnosis. Transmission is autosomal recessive ; however, dominant mutations and compound heterozygotes have been reported.
Mediterranean anemia; Cooley anemia. Iron rich patients need a splenectomy to reduce the probability of an iron overload.
Excess iron causes serious complications within the liver, heart, and endocrine glands. Thalassemia major, intermediate and minor .
It however is not effective in everyone and is probably not suitable in those with significant cardiac issues related to iron overload. Other Mediterranean people, as well as those in the vicinity of the Mediterranean, also have high rates of thalassemia, including people from West Asia and North Africa.
Global annual incidence is estimated at one inArchived from the original on 3 October Family studies can be done to evaluate carrier status and the types of mutations present in other family members.
This is a severe microcytic, hypochromic anemia. Thalassemia can coexist with other hemoglobinopathies. Orphanet J Rare Dis.
To ensure quality blood transfusions, the packed red blood cells should be leucoreduced with a minimum of 40g of hemoglobin content. The most common patient deferoxamine complaint is that they are painful and inconvenient. Multiple blood transfusions can result in iron overload. In other projects Wikimedia Commons. After destroying the affected person’s bone marrow with a dose of chemotherapy a myeloablative conditioning regimenthe altered HSCs are infused back into the affected person where they become engrafted in the bone marrow where they proliferate.
You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted. The peculiar spectrum of beta thalassemia genes in Tunisia.
Thalassemia – Wikipedia
Advances in iron chelation treatments allow patients with thalassemia major to live long lives with access to proper treatment. A child inherits two beta globin genes bb from each parent. Williams Hematology 9e ed.
Depending on your family history, if your parents or grandparents suffered from beta thalassemia there is a high probability of the mutated gene being inherited by an offspring.
Fanconi anemia Diamond—Blackfan anemia Acquired: Advances in Research and Application: Detection and localisation of single base changes by denaturing gradient gel electrephoresis. Blood ; The cost is also significant.